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Compound Detail

CHEMBL3953613

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CNC1(c2ccccc2)CCC2(CC1)OCCc1c2[nH]c2ccccc12

Basic Information

ChEMBL ID CHEMBL3953613
Phase Preclinical
Structure Type MOL
InChI Key CBNHDHDEKMAARV-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

346.5
MW (Da)
4.62
ALogP
2
HBA
2
HBD
37.0
PSA (Ų)
0.71
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H26N2O
MW 346.47
Aromatic Rings 3
Heavy Atoms 26
NP-Likeness 0.26

Activity Summary

Ki 2 meas. best 8.92

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Mu-type opioid receptor
CHEMBL233
Ki 8.92 8.92 1.2 1
Opioid growth factor receptor-like protein 1
CHEMBL3638334
Ki 8.85 8.85 1.4 1

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine