Compound Detail
CHEMBL3955138
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CSCC[C@H](N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C)C(C)C
Basic Information
| ChEMBL ID | CHEMBL3955138 |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | IDGBOQSREBUDEW-QVVOZAQRSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
1751.2
MW (Da)
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.86
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Polymerase acidic protein /RNA-directed RNA polymerase catalytic subunit CHEMBL3885620 | IC50 | 7.86 | 7.86 | 13.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Polymerase acidic protein /RNA-directed RNA polymerase catalytic subunit | IC50 | = | 13.9 | nM | 7.86 | Inhibition of Influenza A virus A/WSN/1933(H1N1) HA-tagged PA/PB1 interaction in... | 27046062 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 27046062 | 10.1021/acs.jmedchem.5b01474 | Polymerase acidic protein /RNA-directed RNA polymerase catalytic subunit | 1 |
Data from ChEMBL 36 via Core Engine