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Compound Detail

CHEMBL3963122

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Clc1cncc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1

Basic Information

ChEMBL ID CHEMBL3963122
Phase Preclinical
Structure Type MOL
InChI Key QURJBQQAYVMKHZ-IBGZPJMESA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

373.9
MW (Da)
2.88
ALogP
5
HBA
0
HBD
37.8
PSA (Ų)
0.78
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H24ClN3O2
MW 373.88
Aromatic Rings 2
Heavy Atoms 26
NP-Likeness -1.55

Activity Summary

Ki 2 meas. best 7.05

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
D(4) dopamine receptor
CHEMBL2574
Ki 7.05 7.05 90.0 1
D(1A) dopamine receptor
CHEMBL3071
Ki 5.23 5.23 5852.0 1

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine