Compound Detail
CHEMBL396831
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O=C1[C@H]2Cc3c([nH]c4ccccc34)[C@@H](c3ccc4c(c3)OCO4)N2C(=O)CN1c1ccc(C(F)(F)F)cc1
Basic Information
| ChEMBL ID | CHEMBL396831 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DQIYHHVHMAJGBK-QFQXNSOFSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
519.5
MW (Da)
4.80
ALogP
4
HBA
1
HBD
74.9
PSA (Ų)
0.41
QED
1
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.42
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| cGMP-specific 3',5'-cyclic phosphodiesterase CHEMBL3478 | IC50 | 6.42 | 6.42 | 377.0 | 1 |
| MRC5 CHEMBL614181 | IC50 | 4.92 | 4.92 | 12000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| cGMP-specific 3',5'-cyclic phosphodiesterase | IC50 | = | 377.0 | nM | 6.42 | Inhibition of bovine PDE5 after 24 hrs by HTRF | 17107795 |
| MRC5 | IC50 | = | 12000.0 | nM | 4.92 | Cytotoxicity against human MRC5 SV2 cells after 72 hrs | 21504142 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17107795 | 10.1016/j.bmcl.2006.10.069 | cGMP-specific 3',5'-cyclic phosphodiesterase | 1 |
| 21504142 | 10.1021/jm1014617 | Plasmodium falciparum | 1 |
| 21504142 | 10.1021/jm1014617 | MRC5 | 1 |
Data from ChEMBL 36 via Core Engine