Assay Detail
Binding
CHEMBL902514
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Inhibition of bovine PDE5 after 24 hrs by HTRF
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL3478) ↗| Type | SINGLE PROTEIN |
| Organism | Bos taurus |
Publication
PDE5 inhibitors: An original access to novel potent arylated analogues of tadalafil.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.24 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL779 | TADALAFIL | 4.0 | 1 | 8.48 |
| CHEMBL247073 | — | — | 1 | 7.80 |
| CHEMBL248087 | — | — | 1 | 7.75 |
| CHEMBL397116 | — | — | 1 | 7.55 |
| CHEMBL397383 | — | — | 1 | 7.28 |
| CHEMBL247893 | — | — | 1 | 7.24 |
| CHEMBL398079 | — | — | 1 | 7.17 |
| CHEMBL245611 | — | — | 1 | 7.04 |
| CHEMBL394999 | — | — | 1 | 6.91 |
| CHEMBL429476 | — | — | 1 | 6.87 |
| CHEMBL394963 | — | — | 1 | 6.85 |
| CHEMBL397115 | — | — | 1 | 6.82 |
| CHEMBL396831 | — | — | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL779 | TADALAFIL | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL247073 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL248087 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL397116 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL397383 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL247893 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL398079 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL245611 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL394999 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL429476 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL394963 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL397115 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL396831 | — | IC50 | = | 377.0 | nM | 6.42 |