Compound Detail
CHEMBL397116
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O=C1[C@H]2Cc3c([nH]c4ccccc34)[C@@H](c3ccc4c(c3)OCO4)N2C(=O)CN1c1cccnc1
Basic Information
| ChEMBL ID | CHEMBL397116 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MWIOKWGKDZZPQQ-CJFMBICVSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
452.5
MW (Da)
3.18
ALogP
5
HBA
1
HBD
87.8
PSA (Ų)
0.50
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.55
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| cGMP-specific 3',5'-cyclic phosphodiesterase CHEMBL3478 | IC50 | 7.55 | 7.55 | 28.0 | 1 |
| Plasmodium falciparum CHEMBL364 | IC50 | 4.66 | 4.66 | 22000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| cGMP-specific 3',5'-cyclic phosphodiesterase | IC50 | = | 28.0 | nM | 7.55 | Inhibition of bovine PDE5 after 24 hrs by HTRF | 17107795 |
| Plasmodium falciparum | IC50 | = | 22000.0 | nM | 4.66 | Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum GH... | 21504142 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17107795 | 10.1016/j.bmcl.2006.10.069 | cGMP-specific 3',5'-cyclic phosphodiesterase | 1 |
| 17107795 | 10.1016/j.bmcl.2006.10.069 | No relevant target | 1 |
| 21504142 | 10.1021/jm1014617 | Plasmodium falciparum | 1 |
| 21504142 | 10.1021/jm1014617 | MRC5 | 1 |
Data from ChEMBL 36 via Core Engine