Compound Detail
CHEMBL3973635
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Basic Information
| ChEMBL ID | CHEMBL3973635 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZJIGGUNEWCTZJO-UHFFFAOYSA-N |
2
Targets
7
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
475.6
MW (Da)
1.23
ALogP
11
HBA
4
HBD
141.0
PSA (Ų)
0.29
QED
1
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 7 meas. best 7.84
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase SYK CHEMBL2599 | IC50 | 7.84 | 7.84 | 14.5 | 6 |
| CD63 antigen CHEMBL3713303 | IC50 | 6.89 | 6.89 | 128.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase SYK | IC50 | = | 14.5 | nM | 7.84 | High Throughput Syk Biochemical Assay: Syk activity was measured using KinEASE (... | - |
| Tyrosine-protein kinase SYK | IC50 | = | 14.5 | nM | 7.84 | Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Immunoassay: Syk ... | - |
| Tyrosine-protein kinase SYK | IC50 | = | 14.5 | nM | 7.84 | Biochemical Assay: Syk activity was measured using KinEASE (Cisbio), a time-reso... | - |
| Tyrosine-protein kinase SYK | IC50 | = | 14.5 | nM | 7.84 | High Throughput Syk Biochemical Assay: Syk activity was measured using KinEASE (... | - |
| Tyrosine-protein kinase SYK | IC50 | = | 14.5 | nM | 7.84 | High Throughput Biochemical Assay: Syk activity was measured using KinEASE (Cisb... | - |
| Tyrosine-protein kinase SYK | IC50 | = | 14.5 | nM | 7.84 | High Throughput Syk Biochemical Assay: Syk activity was measured using KinEASE (... | - |
| CD63 antigen | IC50 | = | 128.0 | nM | 6.89 | High Throughput Syk Biochemical Assay: Syk activity was measured using KinEASE (... | - |
Data from ChEMBL 36 via Core Engine