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Compound Detail

CHEMBL3989562

TERAZOSIN HYDROCHLORIDE
💊 Approved Drug
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💊 Approved Drug
COc1cc2nc(N3CCN(C(=O)C4CCCO4)CC3)nc(N)c2cc1OC.Cl.O.O
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL3989562
Name TERAZOSIN HYDROCHLORIDE
Phase Approved
Structure Type MOL
InChI Key NZMOFYDMGFQZLS-UHFFFAOYSA-N
Therapeutic ✓ Yes
Parent Compound CHEMBL611
Active Moiety CHEMBL611

Known Names

ABBOTT-45975 ABBOTT-45975 ANHYDROUS Benph Heitrin Hytracin Hytrin Hytrin bph Itrin NSC-759168 Terazosin (as hydrochloride) Terazosin hcl Terazosin hcl 2h20 +6 more
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
20
Publications
18
Known Names
2
Indications
1
Mechanisms

Molecular Properties

387.4
MW (Da)
1.06
ALogP
8
HBA
1
HBD
103.0
PSA (Ų)
0.83
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 1987
Availability Prescription
Chirality Racemic

Routes of Administration

Oral
USAN Stem -azosin
USAN Year 1980

Extended Properties

Molecular Formula C19H30ClN5O6
MW 459.93
Aromatic Rings 2
Heavy Atoms 28
NP-Likeness -0.89

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Adrenergic receptor alpha-1 antagonist ANTAGONIST Adrenergic receptor alpha-1 ✓ ✓

Indications

Prostatic Hyperplasia Lewy Body Disease

Literature References

PubMed DOI Target Context # Activities
- 10.6019/CHEMBL5058564 HEK-293T 9
- 10.6019/CHEMBL5058564 U2OS 6
- 10.6019/CHEMBL5058564 Fibroblast 6
- 10.6019/CHEMBL5209801 Glucagon-like peptide 1 receptor 2
- 10.6019/CHEMBL5209801 Alpha-2A adrenergic receptor 2
- 10.6019/CHEMBL5209801 G-protein coupled receptor 35 2
- 10.6019/CHEMBL5209801 Free fatty acid receptor 4 2
- 10.6019/CHEMBL5209801 Apelin receptor 2
- 10.6019/CHEMBL5209801 Glucose-dependent insulinotropic receptor 2
- 10.6019/CHEMBL5209801 N-formyl peptide receptor 2 2
- 10.6019/CHEMBL5209801 Beta-2 adrenergic receptor 2
- 10.6019/CHEMBL5209801 C5a anaphylatoxin chemotactic receptor 1 2
- 10.6019/CHEMBL5209801 CX3C chemokine receptor 1 2
- 10.6019/CHEMBL5209801 Adhesion G-protein coupled receptor F1 2
- 10.6019/CHEMBL5209801 Sphingosine 1-phosphate receptor 1 2
- 10.6019/CHEMBL4808148 Histone deacetylase 6 2
- 10.6019/CHEMBL4495565 SARS-CoV-2 2
- 10.6019/CHEMBL5209801 Type-1 angiotensin II receptor 2
- 10.6019/CHEMBL5060014 Casein kinase I isoform delta 1
- 10.6019/CHEMBL5060014 Cyclin-dependent kinase 2 1

Data from ChEMBL 36 via Core Engine