Compound Detail
CHEMBL398957
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Nc1ncnc2c1c(-c1ccc3[nH]c(Cc4cccc(Cl)c4Cl)nc3c1)nn2[C@H]1CC[C@H](N2CCOCC2)CC1
Basic Information
| ChEMBL ID | CHEMBL398957 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YHFHYEDRUYCUQX-MXVIHJGJSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
577.5
MW (Da)
5.67
ALogP
8
HBA
2
HBD
110.8
PSA (Ų)
0.28
QED
2
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.63
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Insulin-like growth factor 1 receptor CHEMBL1957 | IC50 | 5.63 | 5.63 | 2322.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Insulin-like growth factor 1 receptor | IC50 | = | 2322.0 | nM | 5.63 | Inhibition of human IGF1R expressed in Sf21 cells by time-resolved fluorescence ... | 17689078 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17689078 | 10.1016/j.bmcl.2007.07.037 | Insulin-like growth factor 1 receptor | 2 |
Data from ChEMBL 36 via Core Engine