Compound Detail
CHEMBL3991927
HMN-214 Phase I
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Phase I
Basic Information
| ChEMBL ID | CHEMBL3991927 |
| Name | HMN-214 |
| Phase | Phase I |
| Structure Type | MOL |
| InChI Key | OCKHRKSTDPOHEN-BQYQJAHWSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
20
Publications
2
Known Names
1
Mechanisms
Molecular Properties
424.5
MW (Da)
3.24
ALogP
5
HBA
0
HBD
90.6
PSA (Ų)
0.45
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Serine/threonine-protein kinase PLK1 inhibitor | INHIBITOR | Serine/threonine-protein kinase PLK1 | ✓ | ✓ |
Activity Summary
Kd 1 meas. best 5.86
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Hepatocyte growth factor receptor CHEMBL3717 | Kd | 5.86 | 5.86 | 1393.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Hepatocyte growth factor receptor | Kd | = | 1393.0 | nM | 5.86 | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase ... | 29191878 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29191878 | 10.1126/science.aan4368 | Unchecked | 5 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| 29191878 | 10.1126/science.aan4368 | Activin receptor type-1B | 1 |
| 29191878 | 10.1126/science.aan4368 | RAC-alpha serine/threonine-protein kinase | 1 |
| 29191878 | 10.1126/science.aan4368 | Adenylate kinase 2, mitochondrial | 1 |
| 29191878 | 10.1126/science.aan4368 | Adenosine kinase | 1 |
| 29191878 | 10.1126/science.aan4368 | Uncharacterized aarF domain-containing protein kinase 5 | 1 |
| 29191878 | 10.1126/science.aan4368 | Atypical kinase COQ8A, mitochondrial | 1 |
| 29191878 | 10.1126/science.aan4368 | AarF domain-containing protein kinase 1 | 1 |
| 29191878 | 10.1126/science.aan4368 | Activin receptor type-2B | 1 |
| 38157838 | 10.1016/j.bmc.2023.117561 | Unchecked | 1 |
| 29191878 | 10.1126/science.aan4368 | Actin-related protein 3 | 1 |
| 29191878 | 10.1126/science.aan4368 | Actin-related protein 2 | 1 |
| 29191878 | 10.1126/science.aan4368 | Peroxisomal acyl-coenzyme A oxidase 3 | 1 |
| 29191878 | 10.1126/science.aan4368 | Very long-chain specific acyl-CoA dehydrogenase, mitochondrial | 1 |
| 29191878 | 10.1126/science.aan4368 | Acyl-CoA dehydrogenase family member 11 | 1 |
| 29191878 | 10.1126/science.aan4368 | Acyl-CoA dehydrogenase family member 10 | 1 |
| 29191878 | 10.1126/science.aan4368 | Tyrosine-protein kinase ABL2 | 1 |
Data from ChEMBL 36 via Core Engine