Compound Detail
CHEMBL401505
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Basic Information
| ChEMBL ID | CHEMBL401505 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SAPWBNJQBATSRN-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
357.4
MW (Da)
3.24
ALogP
5
HBA
2
HBD
94.3
PSA (Ų)
0.70
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 5.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| NF-kappa-B inhibitor alpha CHEMBL2898 | EC50 | 5.52 | 5.275 | 3000.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| NF-kappa-B inhibitor alpha | EC50 | = | 3000.0 | nM | 5.52 | Induction of human IkappaBalpha stabilization in OCI-Ly3 cells assessed as ratio... | 18024113 |
| NF-kappa-B inhibitor alpha | EC50 | = | 9400.0 | nM | 5.03 | Induction of human IkappaBalpha stabilization in OCI-Ly3 cells by green light em... | 18024113 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18024113 | 10.1016/j.bmcl.2007.10.100 | NF-kappa-B inhibitor alpha | 3 |
| 18024113 | 10.1016/j.bmcl.2007.10.100 | Transcription factor p65 | 2 |
| 18024113 | 10.1016/j.bmcl.2007.10.100 | Unchecked | 1 |
| 18024113 | 10.1016/j.bmcl.2007.10.100 | NON-PROTEIN TARGET | 1 |
Data from ChEMBL 36 via Core Engine