Assay Detail
Binding
CHEMBL945841
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of human IkappaBalpha stabilization in OCI-Ly3 cells assessed as ratio of green light emiting IkappaBalpha-fused luciferase expression to red light emiting native luciferase expression
39
Total Activities
39
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | OCI-Ly3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFkappaB activity within two separate high-throughput screens of NFkappaB activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 38 | 5.24 | 6.10 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL271669 | — | — | 1 | 6.10 |
| CHEMBL272552 | — | — | 1 | 6.00 |
| CHEMBL404128 | — | — | 1 | 5.85 |
| CHEMBL272553 | — | — | 1 | 5.80 |
| CHEMBL256403 | — | — | 1 | 5.68 |
| CHEMBL273149 | — | — | 1 | 5.64 |
| CHEMBL428064 | — | — | 1 | 5.58 |
| CHEMBL257446 | — | — | 1 | 5.57 |
| CHEMBL401505 | — | — | 1 | 5.52 |
| CHEMBL273147 | — | — | 1 | 5.47 |
| CHEMBL269941 | — | — | 1 | 5.44 |
| CHEMBL256061 | — | — | 1 | 5.40 |
| CHEMBL64925 | MG-132 | — | 1 | 5.28 |
| CHEMBL256609 | — | — | 1 | 5.19 |
| CHEMBL401504 | — | — | 1 | 5.17 |
| CHEMBL273148 | — | — | 1 | 5.14 |
| CHEMBL269942 | — | — | 1 | 5.12 |
| CHEMBL258314 | — | — | 1 | 5.10 |
| CHEMBL256204 | — | — | 1 | 5.10 |
| CHEMBL256062 | — | — | 1 | 5.07 |
| CHEMBL257234 | — | — | 1 | 5.05 |
| CHEMBL270798 | — | — | 1 | 5.00 |
| CHEMBL256042 | — | — | 1 | 5.00 |
| CHEMBL429599 | — | — | 1 | 4.96 |
| CHEMBL403333 | — | — | 1 | 4.96 |
| CHEMBL270799 | — | — | 1 | 4.92 |
| CHEMBL270605 | — | — | 1 | 4.92 |
| CHEMBL402638 | — | — | 1 | 4.89 |
| CHEMBL540966 | — | — | 1 | 4.77 |
| CHEMBL404588 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL271669 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL272552 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL404128 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL272553 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL256403 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL273149 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL428064 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL257446 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL401505 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL273147 | — | EC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL269941 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL256061 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL64925 | MG-132 | EC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL256609 | — | EC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL401504 | — | EC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL273148 | — | EC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL269942 | — | EC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL258314 | — | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL256204 | — | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL256062 | — | EC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL257234 | — | EC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL270798 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL256042 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL429599 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL403333 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL270799 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL270605 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL402638 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL540966 | — | EC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL404588 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL256244 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL257286 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL429586 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL255537 | — | EC50 | - | — | - | |
| CHEMBL270584 | — | EC50 | - | — | - | |
| CHEMBL271233 | — | EC50 | - | — | - | |
| CHEMBL403922 | — | EC50 | > | 57000.0 | nM | - |
| CHEMBL256243 | — | EC50 | > | 57000.0 | nM | - |
| CHEMBL129857 | AS-602868 | Activity | - | — | - |