Compound Detail
CHEMBL401822
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Basic Information
| ChEMBL ID | CHEMBL401822 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ODAGZNANNVQBHU-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
375.3
MW (Da)
3.79
ALogP
6
HBA
1
HBD
58.9
PSA (Ų)
0.74
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.04
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| P2X purinoceptor 7 CHEMBL4805 | IC50 | 8.04 | 8.04 | 9.1 | 1 |
| P2X purinoceptor 7 CHEMBL2496 | IC50 | 7.59 | 7.59 | 25.7 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| P2X purinoceptor 7 | IC50 | = | 9.12 | nM | 8.04 | Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of... | 18272366 |
| P2X purinoceptor 7 | IC50 | = | 25.7 | nM | 7.59 | Antagonist activity at rat recombinant P2X7 receptor assessed as inhibition of B... | 18272366 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18272366 | 10.1016/j.bmcl.2008.01.095 | P2X purinoceptor 7 | 2 |
Data from ChEMBL 36 via Core Engine