Compound Detail
CHEMBL402196
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Basic Information
| ChEMBL ID | CHEMBL402196 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KPDYLYIPGFUWIA-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
167.2
MW (Da)
0.88
ALogP
4
HBA
3
HBD
83.5
PSA (Ų)
0.33
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sucrase-isomaltase, intestinal CHEMBL3114 | IC50 | 8.3 | 6.87 | 5.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sucrase-isomaltase, intestinal | IC50 | = | 5.0 | nM | 8.3 | Inhibition of rat intestinal maltase | 18039578 |
| Sucrase-isomaltase, intestinal | IC50 | = | 3600.0 | nM | 5.44 | Inhibition of rat intestinal sucrase | 18039578 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18039578 | 10.1016/j.bmcl.2007.11.032 | Sucrase-isomaltase, intestinal | 3 |
| 18039578 | 10.1016/j.bmcl.2007.11.032 | Unchecked | 2 |
| 18039578 | 10.1016/j.bmcl.2007.11.032 | Alpha-galactosidase | 1 |
| 18039578 | 10.1016/j.bmcl.2007.11.032 | Beta-galactosidase | 1 |
| 18039578 | 10.1016/j.bmcl.2007.11.032 | Alpha-amylase | 1 |
Data from ChEMBL 36 via Core Engine