Compound Detail
CHEMBL403239
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Basic Information
| ChEMBL ID | CHEMBL403239 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JEPCLNGRAIMPQV-UHFFFAOYSA-N |
1
Targets
3
Activities
2
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
125.1
MW (Da)
0.68
ALogP
3
HBA
3
HBD
66.5
PSA (Ų)
0.35
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.07
Ki 1 meas. best 5.38
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sucrase-isomaltase, intestinal CHEMBL3114 | IC50 | 8.07 | 6.725 | 8.5 | 2 |
| Sucrase-isomaltase, intestinal CHEMBL3114 | Ki | 5.38 | 5.38 | 4200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sucrase-isomaltase, intestinal | IC50 | = | 8.5 | nM | 8.07 | Inhibition of rat intestinal maltase | 18039578 |
| Sucrase-isomaltase, intestinal | IC50 | = | 4200.0 | nM | 5.38 | Inhibition of rat intestinal sucrase | 18039578 |
| Sucrase-isomaltase, intestinal | Ki | = | 4200.0 | nM | 5.38 | Inhibition of sucrose hydrolyzing activity of rat intestinal alpha glucosidase | 18039578 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18039578 | 10.1016/j.bmcl.2007.11.032 | Sucrase-isomaltase, intestinal | 4 |
| 18039578 | 10.1016/j.bmcl.2007.11.032 | Unchecked | 2 |
| 18039578 | 10.1016/j.bmcl.2007.11.032 | Alpha-galactosidase | 1 |
| 18039578 | 10.1016/j.bmcl.2007.11.032 | Beta-galactosidase | 1 |
| 18039578 | 10.1016/j.bmcl.2007.11.032 | Alpha-amylase | 1 |
Data from ChEMBL 36 via Core Engine