Compound Detail
CHEMBL403410
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COc1ccc(C(=O)N2CCN(/C(=N/C#N)Nc3cccc4ncccc34)CC2c2ccccc2)cc1OC
Basic Information
| ChEMBL ID | CHEMBL403410 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KMQDXQUTSKJMBL-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
520.6
MW (Da)
4.70
ALogP
6
HBA
1
HBD
103.1
PSA (Ų)
0.23
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| P2X purinoceptor 7 CHEMBL2496 | IC50 | 7.52 | 7.52 | 30.0 | 1 |
| P2X purinoceptor 7 CHEMBL4805 | IC50 | 7.23 | 7.23 | 59.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| P2X purinoceptor 7 | IC50 | = | 30.0 | nM | 7.52 | Antagonist activity at rat recombinant P2X7 receptor assessed as inhibition of c... | 18272365 |
| P2X purinoceptor 7 | IC50 | = | 59.0 | nM | 7.23 | Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of... | 18272365 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18272365 | 10.1016/j.bmcl.2008.01.094 | P2X purinoceptor 7 | 2 |
| 18272365 | 10.1016/j.bmcl.2008.01.094 | P2X purinoceptor 3 | 1 |
| 18272365 | 10.1016/j.bmcl.2008.01.094 | Unchecked | 1 |
| 18272365 | 10.1016/j.bmcl.2008.01.094 | P2X purinoceptor 4 | 1 |
| 18272365 | 10.1016/j.bmcl.2008.01.094 | P2Y purinoceptor 2 | 1 |
Data from ChEMBL 36 via Core Engine