Compound Detail
CHEMBL4059854
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Basic Information
| ChEMBL ID | CHEMBL4059854 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IATRELKTSMOMBJ-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
298.4
MW (Da)
3.58
ALogP
4
HBA
1
HBD
74.0
PSA (Ų)
0.87
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 7.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Solute carrier family 22 member 12 CHEMBL6120 | EC50 | 7.6 | 7.59 | 25.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Solute carrier family 22 member 12 | EC50 | = | 25.0 | nM | 7.6 | URAT1-Model Assay: HEK293 human embryonic kidney cells (ATCC #CRL-1573) were pro... | - |
| Solute carrier family 22 member 12 | EC50 | = | 26.0 | nM | 7.58 | URAT1-Model Assay: HEK293 human embryonic kidney cells (ATCC# CRL-1573) were pro... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28351592 | 10.1016/j.bmcl.2017.03.041 | Solute carrier family 22 member 12 | 1 |
Data from ChEMBL 36 via Core Engine