Compound Detail
CHEMBL4060714
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Basic Information
| ChEMBL ID | CHEMBL4060714 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ASBSOCYVAYZKGS-UHFFFAOYSA-N |
3
Targets
3
Activities
2
Assay Types
1
PK Parameters
4
Publications
0
Known Names
Molecular Properties
343.4
MW (Da)
3.56
ALogP
6
HBA
1
HBD
78.1
PSA (Ų)
0.79
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.33
EC50 1 meas. best 7.8
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| CDK8/Cyclin C CHEMBL3038474 | IC50 | 8.33 | 8.33 | 4.7 | 1 |
| Cyclin-C/Cyclin-dependent kinase 19 CHEMBL3883323 | IC50 | 8.18 | 8.18 | 6.6 | 1 |
| Cyclin-dependent kinase 8 CHEMBL5719 | EC50 | 7.8 | 7.8 | 16.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 65.0 | mL.min-1.g-1 | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| CDK8/Cyclin C | IC50 | = | 4.7 | nM | 8.33 | Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown orig... | 28302507 |
| Cyclin-C/Cyclin-dependent kinase 19 | IC50 | = | 6.6 | nM | 8.18 | Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown ori... | 28302507 |
| Cyclin-dependent kinase 8 | EC50 | = | 16.0 | nM | 7.8 | Inhibition of CDK8 in human SW620 cells assessed as decrease in STAT1 phosphoryl... | 28302507 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28302507 | 10.1016/j.bmc.2017.02.038 | Cyclin-C/Cyclin-dependent kinase 19 | 1 |
| 28302507 | 10.1016/j.bmc.2017.02.038 | Cyclin-dependent kinase 8 | 1 |
| 28302507 | 10.1016/j.bmc.2017.02.038 | CDK8/Cyclin C | 1 |
| 28302507 | 10.1016/j.bmc.2017.02.038 | Liver | 1 |
Data from ChEMBL 36 via Core Engine