Compound Detail
CHEMBL4063976
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Basic Information
| ChEMBL ID | CHEMBL4063976 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FRIXDVCUSGTPAF-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
375.4
MW (Da)
4.79
ALogP
3
HBA
4
HBD
102.4
PSA (Ų)
0.53
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.74
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 4.74 | 4.74 | 18325.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 | IC50 | = | 18325.0 | nM | 4.74 | Inhibition of FGFR1 (unknown origin) using FAM-labeled peptide as substrate prei... | 28541695 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28541695 | 10.1021/acs.jmedchem.7b00468 | Fibroblast growth factor receptor 1 | 1 |
| 28541695 | 10.1021/acs.jmedchem.7b00468 | Platelet-derived growth factor receptor alpha | 1 |
| 28541695 | 10.1021/acs.jmedchem.7b00468 | Vascular endothelial growth factor receptor 2 | 1 |
Data from ChEMBL 36 via Core Engine