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Compound Detail

CHEMBL4067904

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CC(C)C[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)CN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)NCC(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O

Basic Information

ChEMBL ID CHEMBL4067904
Phase Preclinical
Structure Type MOL
InChI Key ICMJQIXGFJMTDS-QIDPRFCVSA-N
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

1701.7
MW (Da)

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C65H108N26O28
MW 1701.73

Activity Summary

IC50 3 meas. best 4.6

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Integrin alpha-V/beta-5
CHEMBL2096675
IC50 4.6 4.6 25000.0 1
Integrin alpha-V/beta-3/alpha-V/beta-5
CHEMBL4106150
IC50 4.13 4.13 74000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
28351594 10.1016/j.bmcl.2017.03.035 Integrin alpha-V/beta-3 1
28351594 10.1016/j.bmcl.2017.03.035 Integrin alpha-V/beta-3/alpha-V/beta-5 1
28351594 10.1016/j.bmcl.2017.03.035 Integrin alpha-V/beta-5 1

Data from ChEMBL 36 via Core Engine