Assay Detail
Binding
CHEMBL4015174
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at integrin alphaVbeta3alphaVbeta5 (unknown origin) expressed in SKOV3 cells assessed as reduction in cell adhesion to fibrinogen after 2 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Integrin alpha-V/beta-3/alpha-V/beta-5 (CHEMBL4106150) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
New potent and selective αvβ3 integrin ligands: Macrocyclic peptides containing RGD motif synthesized by sortase A-mediated ligation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.05 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL429876 | CILENGITIDE | 3.0 | 1 | 6.43 |
| CHEMBL4085518 | — | — | 1 | 5.40 |
| CHEMBL4079738 | — | — | 1 | 4.72 |
| CHEMBL4097763 | — | — | 1 | 4.58 |
| CHEMBL4067904 | — | — | 1 | 4.13 |
| CHEMBL4068971 | — | — | 1 | - |
| CHEMBL4090048 | — | — | 1 | - |
| CHEMBL141005 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL429876 | CILENGITIDE | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL4085518 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4079738 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL4097763 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL4067904 | — | IC50 | = | 74000.0 | nM | 4.13 |
| CHEMBL4068971 | — | IC50 | = | 136000.0 | nM | - |
| CHEMBL4090048 | — | IC50 | = | 102000.0 | nM | - |
| CHEMBL141005 | — | IC50 | = | 753000.0 | nM | - |