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Compound Detail

CHEMBL4085518

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CC(C)C[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CNC(=O)CNC(=O)CN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)NCC(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O

Basic Information

ChEMBL ID CHEMBL4085518
Phase Preclinical
Structure Type MOL
InChI Key OTPJHCLEDMTCQA-NMYCIVIXSA-N
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

1544.6
MW (Da)

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C59H97N23O26
MW 1544.56

Activity Summary

IC50 3 meas. best 5.4

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Integrin alpha-V/beta-3/alpha-V/beta-5
CHEMBL4106150
IC50 5.4 5.4 4000.0 1
Integrin alpha-V/beta-3
CHEMBL1907598
IC50 4.48 4.48 33000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
28351594 10.1016/j.bmcl.2017.03.035 Unchecked 2
28351594 10.1016/j.bmcl.2017.03.035 Integrin alpha-V/beta-3 1
28351594 10.1016/j.bmcl.2017.03.035 Integrin alpha-V/beta-3/alpha-V/beta-5 1
28351594 10.1016/j.bmcl.2017.03.035 Integrin alpha-V/beta-5 1

Data from ChEMBL 36 via Core Engine