Compound Detail
CHEMBL4068475
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CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O
Basic Information
| ChEMBL ID | CHEMBL4068475 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QEPJRHCJSLUZAD-UDQMZMDLSA-N |
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
1508.8
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.77
EC50 1 meas. best 6.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Melanocortin receptor 3 CHEMBL4644 | IC50 | 7.77 | 7.77 | 17.0 | 1 |
| Melanocyte-stimulating hormone receptor CHEMBL3795 | IC50 | 6.86 | 6.86 | 137.0 | 1 |
| Melanocyte-stimulating hormone receptor CHEMBL3795 | EC50 | 6.22 | 6.22 | 604.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Melanocortin receptor 3 | IC50 | = | 17.0 | nM | 7.77 | Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells a... | 29094944 |
| Melanocyte-stimulating hormone receptor | IC50 | = | 137.0 | nM | 6.86 | Displacement of [125I]-NDP-alpha-MSH from human MC1R expressed in HEK293 cells a... | 29094944 |
| Melanocyte-stimulating hormone receptor | EC50 | = | 604.0 | nM | 6.22 | Agonist activity at human MC1R expressed in HEK293 cells assessed as induction o... | 29094944 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29094944 | 10.1021/acs.jmedchem.7b01295 | Melanocyte-stimulating hormone receptor | 4 |
| 29094944 | 10.1021/acs.jmedchem.7b01295 | Melanocortin receptor 3 | 4 |
| 29094944 | 10.1021/acs.jmedchem.7b01295 | Melanocortin receptor 4 | 4 |
| 29094944 | 10.1021/acs.jmedchem.7b01295 | Melanocortin receptor 5 | 4 |
Data from ChEMBL 36 via Core Engine