Compound Detail
CHEMBL4072316
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL4072316 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GAGSUJFFXBSIDN-CPCISQLKSA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
334.2
MW (Da)
0.36
ALogP
7
HBA
5
HBD
184.2
PSA (Ų)
0.27
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 4 meas. best 6.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 4 CHEMBL2736 | EC50 | 6.3 | 6.3 | 500.0 | 1 |
| Metabotropic glutamate receptor 6 CHEMBL4573 | EC50 | 5.44 | 5.44 | 3600.0 | 1 |
| Metabotropic glutamate receptor 8 CHEMBL3228 | EC50 | 4.5 | 4.5 | 31400.0 | 1 |
| Metabotropic glutamate receptor 7 CHEMBL3777 | EC50 | 4.21 | 4.21 | 62000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 4 | EC50 | = | 500.0 | nM | 6.3 | Agonist activity at mGlu4 (unknown origin) expressed in HEK293 cells coexpressin... | 29397723 |
| Metabotropic glutamate receptor 6 | EC50 | = | 3600.0 | nM | 5.44 | Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressin... | 29397723 |
| Metabotropic glutamate receptor 8 | EC50 | = | 31400.0 | nM | 4.5 | Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressin... | 29397723 |
| Metabotropic glutamate receptor 7 | EC50 | = | 62000.0 | nM | 4.21 | Agonist activity at mGlu7 (unknown origin) expressed in HEK293 cells coexpressin... | 29397723 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29397723 | 10.1021/acs.jmedchem.7b01438 | Metabotropic glutamate receptor 6 | 1 |
| 29397723 | 10.1021/acs.jmedchem.7b01438 | Metabotropic glutamate receptor 7 | 1 |
| 29397723 | 10.1021/acs.jmedchem.7b01438 | Metabotropic glutamate receptor 4 | 1 |
| 29397723 | 10.1021/acs.jmedchem.7b01438 | Metabotropic glutamate receptor 8 | 1 |
| 29397723 | 10.1021/acs.jmedchem.7b01438 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine