Compound Detail
CHEMBL4073935
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Basic Information
| ChEMBL ID | CHEMBL4073935 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UBOQKPCXNYZXEW-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
215.3
MW (Da)
1.67
ALogP
2
HBA
3
HBD
84.9
PSA (Ų)
0.67
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 4.66
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Bromodomain-containing protein 4 CHEMBL1163125 | Ki | 4.66 | 4.66 | 22000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Bromodomain-containing protein 4 | Ki | = | 22000.0 | nM | 4.66 | Binding affinity to His-tagged BRD4 BD1-BD2 (K57 to K550 residues) (unknown orig... | 28268136 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28268136 | 10.1016/j.bmcl.2017.02.057 | Bromodomain-containing protein 4 | 2 |
| 28268136 | 10.1016/j.bmcl.2017.02.057 | MX1 | 1 |
Data from ChEMBL 36 via Core Engine