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Compound Detail

CHEMBL4075646

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Cn1cc(O)c(=O)cc1/C=C/c1ccc(Cl)cc1

Basic Information

ChEMBL ID CHEMBL4075646
Phase Preclinical
Structure Type MOL
InChI Key WZPUKSJKRALPHZ-QPJJXVBHSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

261.7
MW (Da)
2.91
ALogP
3
HBA
1
HBD
42.2
PSA (Ų)
0.90
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C14H12ClNO2
MW 261.71
Aromatic Rings 2
Heavy Atoms 18
NP-Likeness -0.05

Activity Summary

IC50 1 meas. best 5.24

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
No relevant target
CHEMBL2362975
IC50 5.24 5.24 5720.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
No relevant target IC50 = 5720.0 nM 5.24 Antioxidant activity assessed as ABTS radical scavenging activity incubated for ... 28061347

Literature References

PubMed DOI Target Context # Activities
28061347 10.1016/j.ejmech.2016.12.045 No relevant target 2
28061347 10.1016/j.ejmech.2016.12.045 Amyloid-beta precursor protein 2

Data from ChEMBL 36 via Core Engine