Compound Detail
CHEMBL4081837
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Basic Information
| ChEMBL ID | CHEMBL4081837 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NPNATZWDBSJWKE-OAHLLOKOSA-N |
1
Targets
3
Activities
1
Assay Types
2
PK Parameters
4
Publications
0
Known Names
Molecular Properties
394.4
MW (Da)
3.63
ALogP
4
HBA
2
HBD
80.5
PSA (Ų)
0.83
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.24
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Lysyl oxidase homolog 2 CHEMBL3714029 | IC50 | 6.24 | 5.6167 | 570.0 | 3 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| Cmax | - | - | Mus musculus |
| Cmax | - | - | Mus musculus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Lysyl oxidase homolog 2 | IC50 | = | 570.0 | nM | 6.24 | Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 p... | 28471663 |
| Lysyl oxidase homolog 2 | IC50 | = | 620.0 | nM | 6.21 | Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 p... | 28471663 |
| Lysyl oxidase homolog 2 | IC50 | = | 40000.0 | nM | 4.4 | Inhibition of recombinant human LOXL2 expressed in human whole blood assessed as... | 28471663 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28471663 | 10.1021/acs.jmedchem.7b00345 | Lysyl oxidase homolog 2 | 3 |
| 28471663 | 10.1021/acs.jmedchem.7b00345 | Protein-lysine 6-oxidase | 1 |
| 28471663 | 10.1021/acs.jmedchem.7b00345 | Lung | 1 |
| 28471663 | 10.1021/acs.jmedchem.7b00345 | Plasma | 1 |
Data from ChEMBL 36 via Core Engine