Compound Detail
CHEMBL4082023
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Basic Information
| ChEMBL ID | CHEMBL4082023 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZEBYXZHDTZMGNC-SANMLTNESA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
450.5
MW (Da)
5.75
ALogP
5
HBA
3
HBD
83.1
PSA (Ų)
0.29
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 2 CHEMBL4142 | IC50 | 7.0 | 7.0 | 100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 2 | IC50 | = | 100.0 | nM | 7.0 | Inhibition of recombinant human FGFR2 using poly (Glu,Tyr) 4:1 as substrate afte... | 28714692 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28714692 | 10.1021/acs.jmedchem.7b00076 | Fibroblast growth factor receptor 2 | 1 |
| 28714692 | 10.1021/acs.jmedchem.7b00076 | Fibroblast growth factor receptor 1 | 1 |
| 28714692 | 10.1021/acs.jmedchem.7b00076 | Fibroblast growth factor receptor 3 | 1 |
Data from ChEMBL 36 via Core Engine