Assay Detail
Binding
CHEMBL4018626
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human FGFR2 using poly (Glu,Tyr) 4:1 as substrate after 60 mins by ELISA
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Pharmacological Evaluation of Novel Multisubstituted Pyridin-3-amine Derivatives as Multitargeted Protein Kinase Inhibitors for the Treatment of Non-Small Cell Lung Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 7.75 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3348846 | FEXAGRATINIB | 2.0 | 1 | 8.96 |
| CHEMBL4062877 | — | — | 1 | 8.80 |
| CHEMBL4067871 | — | — | 1 | 8.70 |
| CHEMBL4076118 | — | — | 1 | 8.60 |
| CHEMBL4074407 | — | — | 1 | 8.55 |
| CHEMBL4073545 | — | — | 1 | 8.52 |
| CHEMBL4077448 | — | — | 1 | 8.47 |
| CHEMBL4075917 | — | — | 1 | 8.33 |
| CHEMBL4082721 | — | — | 1 | 8.18 |
| CHEMBL4105329 | — | — | 1 | 8.07 |
| CHEMBL4084388 | — | — | 1 | 7.79 |
| CHEMBL4100031 | — | — | 1 | 7.67 |
| CHEMBL4086068 | — | — | 1 | 7.58 |
| CHEMBL4071491 | — | — | 1 | 7.35 |
| CHEMBL4084547 | — | — | 1 | 7.30 |
| CHEMBL4060706 | — | — | 1 | 7.25 |
| CHEMBL4078176 | — | — | 1 | 7.25 |
| CHEMBL4095830 | — | — | 1 | 7.14 |
| CHEMBL4094883 | — | — | 1 | 7.14 |
| CHEMBL4102447 | — | — | 1 | 7.00 |
| CHEMBL4083543 | — | — | 1 | 7.00 |
| CHEMBL4082023 | — | — | 1 | 7.00 |
| CHEMBL4077119 | — | — | 1 | 6.81 |
| CHEMBL4062871 | — | — | 1 | 6.60 |
| CHEMBL4102355 | — | — | 1 | - |
| CHEMBL4092280 | — | — | 1 | - |
| CHEMBL4063010 | — | — | 1 | - |
| CHEMBL4075768 | — | — | 1 | - |
| CHEMBL4082577 | — | — | 1 | - |
| CHEMBL4064545 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3348846 | FEXAGRATINIB | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4062877 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4067871 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4076118 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4074407 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL4073545 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4077448 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL4075917 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL4082721 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL4105329 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL4084388 | — | IC50 | = | 16.1 | nM | 7.79 |
| CHEMBL4100031 | — | IC50 | = | 21.4 | nM | 7.67 |
| CHEMBL4086068 | — | IC50 | = | 26.3 | nM | 7.58 |
| CHEMBL4071491 | — | IC50 | = | 44.6 | nM | 7.35 |
| CHEMBL4084547 | — | IC50 | = | 50.5 | nM | 7.30 |
| CHEMBL4060706 | — | IC50 | = | 56.4 | nM | 7.25 |
| CHEMBL4078176 | — | IC50 | = | 56.9 | nM | 7.25 |
| CHEMBL4095830 | — | IC50 | = | 71.9 | nM | 7.14 |
| CHEMBL4094883 | — | IC50 | = | 72.9 | nM | 7.14 |
| CHEMBL4102447 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4083543 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4082023 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4077119 | — | IC50 | = | 153.5 | nM | 6.81 |
| CHEMBL4062871 | — | IC50 | = | 250.2 | nM | 6.60 |
| CHEMBL4101542 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4068491 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4100109 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4101681 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4091460 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4064545 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4082577 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4075768 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4063010 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4092280 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4102355 | — | IC50 | > | 1000.0 | nM | - |