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Compound Detail

CHEMBL4089616

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CC(C)(C)C1CCc2c(sc3c2c(=O)n(-c2ccc(Cl)cc2)c2nncn32)C1

Basic Information

ChEMBL ID CHEMBL4089616
Phase Preclinical
Structure Type MOL
InChI Key MFRACPLNOMGXAC-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names

Molecular Properties

412.9
MW (Da)
4.90
ALogP
6
HBA
0
HBD
52.2
PSA (Ų)
0.45
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H21ClN4OS
MW 412.95
Aromatic Rings 4
Heavy Atoms 28
NP-Likeness -1.86

Activity Summary

EC50 3 meas. best 5.43

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
rhinovirus B14
CHEMBL613759
EC50 5.43 5.43 3700.0 1
Unchecked
CHEMBL612545
EC50 5.42 5.42 3800.0 1
Poliovirus 3
CHEMBL613557
EC50 5.08 5.08 8350.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

Data from ChEMBL 36 via Core Engine