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Assay Detail

CHEMBL4036487

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against human rhinovirus 14 infected in human H1HeLa cells assessed as reduction in virus-induced cytopathicity incubated for 3 days by MTT assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism rhinovirus B14
Confidence 1 — Organism
Curated By Autocuration

Target

rhinovirus B14 (CHEMBL613759)
Type ORGANISM
Organism rhinovirus B14

Publication

Enterovirus inhibitory activity of C-8-tert-butyl substituted 4-aryl-6,7,8,9-tetrahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-ones.
Kumar Biswas B, Malpani YR, Ha N, Kwon DH, Soo Shin J, Kim HS, Kim C, Bong Han S, Lee CK, Jung YS.
Bioorg Med Chem Lett (2017) 27 : 3582 -3585
PubMed 28587824 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 23 5.40 6.51

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL29609 PLECONARIL 2.0 1 6.51
CHEMBL4059872 1 5.77
CHEMBL4099763 1 5.75
CHEMBL4092018 1 5.72
CHEMBL4062556 1 5.70
CHEMBL4061491 1 5.68
CHEMBL4081742 1 5.60
CHEMBL4084264 1 5.46
CHEMBL4089616 1 5.43
CHEMBL4067440 1 5.37
CHEMBL4099349 1 5.09
CHEMBL4079352 1 5.06
CHEMBL4070725 1 5.00
CHEMBL4098298 1 4.79
CHEMBL4088137 1 4.74
CHEMBL4095864 1 4.71
CHEMBL4080258 1 -
CHEMBL4066756 1 -
CHEMBL4081329 1 -
CHEMBL4088678 1 -
CHEMBL4071191 1 -
CHEMBL4090567 1 -
CHEMBL4103617 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL29609 PLECONARIL EC50 = 310.0 nM 6.51
CHEMBL4059872 EC50 = 1700.0 nM 5.77
CHEMBL4099763 EC50 = 1800.0 nM 5.75
CHEMBL4092018 EC50 = 1900.0 nM 5.72
CHEMBL4062556 EC50 = 2000.0 nM 5.70
CHEMBL4061491 EC50 = 2100.0 nM 5.68
CHEMBL4081742 EC50 = 2500.0 nM 5.60
CHEMBL4084264 EC50 = 3500.0 nM 5.46
CHEMBL4089616 EC50 = 3700.0 nM 5.43
CHEMBL4067440 EC50 = 4300.0 nM 5.37
CHEMBL4099349 EC50 = 8200.0 nM 5.09
CHEMBL4079352 EC50 = 8800.0 nM 5.06
CHEMBL4070725 EC50 = 10100.0 nM 5.00
CHEMBL4098298 EC50 = 16400.0 nM 4.79
CHEMBL4088137 EC50 = 18100.0 nM 4.74
CHEMBL4095864 EC50 = 19400.0 nM 4.71
CHEMBL4080258 EC50 > 100000.0 nM -
CHEMBL4066756 EC50 > 76500.0 nM -
CHEMBL4081329 EC50 > 8700.0 nM -
CHEMBL4088678 EC50 > 16900.0 nM -
CHEMBL4071191 EC50 > 31400.0 nM -
CHEMBL4090567 EC50 > 100000.0 nM -
CHEMBL4103617 EC50 > 9600.0 nM -