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Compound Detail

CHEMBL4099763

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Cc1ccc(-n2c(=O)c3c4c(sc3n3cnnc23)CC(C(C)(C)C)CC4)cc1

Basic Information

ChEMBL ID CHEMBL4099763
Phase Preclinical
Structure Type MOL
InChI Key MHESBTSARFOFCO-UHFFFAOYSA-N
6
Targets
6
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names

Molecular Properties

392.5
MW (Da)
4.55
ALogP
6
HBA
0
HBD
52.2
PSA (Ų)
0.48
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H24N4OS
MW 392.53
Aromatic Rings 4
Heavy Atoms 28
NP-Likeness -1.76

Activity Summary

EC50 6 meas. best 5.75

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
EC50 5.75 5.75 1800.0 1
rhinovirus B14
CHEMBL613759
EC50 5.75 5.75 1800.0 1
Poliovirus 3
CHEMBL613557
EC50 5.71 5.71 1940.0 1
rhinovirus A21
CHEMBL612371
EC50 5.62 5.62 2400.0 1
Coxsackievirus B3
CHEMBL613554
EC50 4.89 4.89 12880.0 1
Coxsackievirus B1
CHEMBL612677
EC50 4.84 4.84 14320.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

Data from ChEMBL 36 via Core Engine