Compound Detail
CHEMBL4090312
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL4090312 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HHOMYPVGQXHCJJ-FTNKSUMCSA-N |
3
Targets
5
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
288.2
MW (Da)
0.33
ALogP
5
HBA
5
HBD
146.9
PSA (Ų)
0.37
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 5 meas. best 5.08
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 8 CHEMBL3228 | EC50 | 5.08 | 5.08 | 8400.0 | 2 |
| Metabotropic glutamate receptor 4 CHEMBL2736 | EC50 | 5.06 | 5.06 | 8800.0 | 2 |
| Metabotropic glutamate receptor 7 CHEMBL3777 | EC50 | 4.94 | 4.94 | 11600.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 8 | EC50 | = | 8400.0 | nM | 5.08 | Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressin... | 29397723 |
| Metabotropic glutamate receptor 8 | EC50 | = | 8400.0 | nM | 5.08 | Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressin... | 29397723 |
| Metabotropic glutamate receptor 4 | EC50 | = | 8800.0 | nM | 5.06 | Agonist activity at mGlu4 (unknown origin) expressed in HEK293 cells coexpressin... | 29397723 |
| Metabotropic glutamate receptor 4 | EC50 | = | 8800.0 | nM | 5.06 | Agonist activity at mGlu4 (unknown origin) expressed in HEK293 cells coexpressin... | 29397723 |
| Metabotropic glutamate receptor 7 | EC50 | = | 11600.0 | nM | 4.94 | Agonist activity at mGlu7 (unknown origin) expressed in HEK293 cells coexpressin... | 29397723 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29397723 | 10.1021/acs.jmedchem.7b01438 | Metabotropic glutamate receptor 4 | 2 |
| 29397723 | 10.1021/acs.jmedchem.7b01438 | Metabotropic glutamate receptor 8 | 2 |
| 29397723 | 10.1021/acs.jmedchem.7b01438 | Unchecked | 2 |
| 29397723 | 10.1021/acs.jmedchem.7b01438 | Metabotropic glutamate receptor 7 | 1 |
Data from ChEMBL 36 via Core Engine