Compound Detail
CHEMBL4091566
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Basic Information
| ChEMBL ID | CHEMBL4091566 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KZZVYUYRNIMTBP-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
420.5
MW (Da)
2.96
ALogP
6
HBA
3
HBD
112.7
PSA (Ų)
0.40
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.01
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Rho-associated protein kinase 2 CHEMBL2973 | IC50 | 7.01 | 7.01 | 98.0 | 1 |
| Beta-adrenergic receptor kinase 1 CHEMBL4079 | IC50 | 7.0 | 7.0 | 100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Rho-associated protein kinase 2 | IC50 | = | 98.0 | nM | 7.01 | Inhibition of recombinant human N-terminal GST-tagged ROCK2 catalytic domain (1 ... | 28699740 |
| Beta-adrenergic receptor kinase 1 | IC50 | = | 100.0 | nM | 7.0 | Inhibition of recombinant human N-terminal GST-tagged GRK2 expressed in baculovi... | 28699740 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28699740 | 10.1021/acs.jmedchem.7b00443 | Beta-adrenergic receptor kinase 1 | 1 |
| 28699740 | 10.1021/acs.jmedchem.7b00443 | Rho-associated protein kinase 2 | 1 |
| 28699740 | 10.1021/acs.jmedchem.7b00443 | Protein kinase C alpha type | 1 |
| 28699740 | 10.1021/acs.jmedchem.7b00443 | Cytochrome P450 3A4 | 1 |
Data from ChEMBL 36 via Core Engine