Compound Detail
CHEMBL4091770
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Basic Information
| ChEMBL ID | CHEMBL4091770 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NPEZDULFGPLXGJ-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
510.1
MW (Da)
7.27
ALogP
4
HBA
0
HBD
30.9
PSA (Ų)
0.30
QED
2
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 3 meas. best 6.39
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Ionotropic glutamate receptor NMDA 1/2D CHEMBL3038506 | EC50 | 6.39 | 6.39 | 410.0 | 1 |
| Glutamate NMDA receptor; Grin1/Grin2c CHEMBL2096911 | EC50 | 6.32 | 6.32 | 480.0 | 1 |
| Glutamate NMDA receptor; Grin1/Grin2b CHEMBL2096666 | EC50 | 6.26 | 6.26 | 550.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Ionotropic glutamate receptor NMDA 1/2D | EC50 | = | 410.0 | nM | 6.39 | Positive allosteric modulation of recombinant rat GluN1/GluN2D receptor expresse... | 28586221 |
| Glutamate NMDA receptor; Grin1/Grin2c | EC50 | = | 480.0 | nM | 6.32 | Positive allosteric modulation of recombinant rat GluN1/GluN2C receptor expresse... | 28586221 |
| Glutamate NMDA receptor; Grin1/Grin2b | EC50 | = | 550.0 | nM | 6.26 | Positive allosteric modulation of recombinant rat GluN1/GluN2B receptor expresse... | 28586221 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28586221 | 10.1021/acs.jmedchem.7b00239 | Glutamate NMDA receptor; Grin1/Grin2b | 3 |
| 28586221 | 10.1021/acs.jmedchem.7b00239 | Glutamate NMDA receptor; Grin1/Grin2c | 2 |
| 28586221 | 10.1021/acs.jmedchem.7b00239 | Ionotropic glutamate receptor NMDA 1/2D | 2 |
Data from ChEMBL 36 via Core Engine