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Compound Detail

CHEMBL409827

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O=C(O)c1ccc(Nc2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1

Basic Information

ChEMBL ID CHEMBL409827
Phase Preclinical
Structure Type MOL
InChI Key JORZYQDONOCUPN-QFIPXVFZSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

410.9
MW (Da)
4.65
ALogP
4
HBA
4
HBD
81.6
PSA (Ų)
0.39
QED
0
Ro5 Violations
9
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H23ClN2O3
MW 410.90
Aromatic Rings 3
Heavy Atoms 29
NP-Likeness -0.72

Activity Summary

EC50 2 meas. best 8.41

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-1 adrenergic receptor
CHEMBL213
EC50 8.41 8.41 3.9 1
Beta-3 adrenergic receptor
CHEMBL246
EC50 8.34 8.34 4.6 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
18307290 10.1021/jm701324c Beta-3 adrenergic receptor 2
18307290 10.1021/jm701324c Canis familiaris 2
18307290 10.1021/jm701324c Beta-1 adrenergic receptor 1
18307290 10.1021/jm701324c Unchecked 1

Data from ChEMBL 36 via Core Engine