Compound Detail
CHEMBL4102202
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Basic Information
| ChEMBL ID | CHEMBL4102202 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RDIHPXYAMGYXKA-ALCCZGGFSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
324.2
MW (Da)
3.09
ALogP
5
HBA
1
HBD
81.0
PSA (Ų)
0.68
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 5.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Dual specificity protein kinase CLK1 CHEMBL4224 | EC50 | 5.1 | 5.1 | 8000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Dual specificity protein kinase CLK1 | EC50 | = | 8000.0 | nM | 5.1 | Inhibition of CLK mediated SF3B1 activation in human SK-MEL-2 cells assessed as ... | 28049589 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28049589 | 10.1016/j.bmcl.2016.12.056 | Dual specificity protein kinase CLK1 | 2 |
Data from ChEMBL 36 via Core Engine