Compound Detail
CHEMBL4111192
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Basic Information
| ChEMBL ID | CHEMBL4111192 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZOJSOVGLNPJZLG-VUUHIHSGSA-N |
2
Targets
6
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
347.3
MW (Da)
0.21
ALogP
6
HBA
5
HBD
167.4
PSA (Ų)
0.39
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 6 meas. best 5.31
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 4 CHEMBL2787 | EC50 | 5.31 | 5.1067 | 4900.0 | 3 |
| Metabotropic glutamate receptor 8 CHEMBL2718 | EC50 | 4.53 | 4.3733 | 29300.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 4 | EC50 | = | 4900.0 | nM | 5.31 | Pharmacological Assay: Metabotropic glutamate receptors were transiently transfe... | - |
| Metabotropic glutamate receptor 4 | EC50 | = | 7600.0 | nM | 5.12 | Pharmacological Assay: Metabotropic glutamate receptors were transiently transfe... | - |
| Metabotropic glutamate receptor 4 | EC50 | = | 13000.0 | nM | 4.89 | Pharmacological Assay: Metabotropic glutamate receptors were transiently transfe... | - |
| Metabotropic glutamate receptor 8 | EC50 | = | 29300.0 | nM | 4.53 | Pharmacological Assay: Metabotropic glutamate receptors were transiently transfe... | - |
| Metabotropic glutamate receptor 8 | EC50 | = | 36000.0 | nM | 4.44 | Pharmacological Assay: Metabotropic glutamate receptors were transiently transfe... | - |
| Metabotropic glutamate receptor 8 | EC50 | = | 71000.0 | nM | 4.15 | Pharmacological Assay: Metabotropic glutamate receptors were transiently transfe... | - |
Data from ChEMBL 36 via Core Engine