Compound Detail
CHEMBL4113689
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Basic Information
| ChEMBL ID | CHEMBL4113689 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MXNZXCMSAPNVDA-CHWSQXEVSA-N |
1
Targets
5
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
378.4
MW (Da)
3.62
ALogP
6
HBA
2
HBD
71.7
PSA (Ų)
0.73
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 7.44
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-1 CHEMBL2147 | IC50 | 7.44 | 7.44 | 36.0 | 5 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-1 | IC50 | = | 36.0 | nM | 7.44 | Kinase-Glo Assay: These assays are set up in duplicate 50 ul volumes in white, f... | - |
| Serine/threonine-protein kinase pim-1 | IC50 | = | 36.0 | nM | 7.44 | Kinase-Glo Assay: These assays are set up in duplicate 50 ul volumes in white, f... | - |
| Serine/threonine-protein kinase pim-1 | IC50 | = | 36.0 | nM | 7.44 | Pim-1 Kinase Inhibition Assay: One illustrative manner in which Pim-1 kinase act... | - |
| Serine/threonine-protein kinase pim-1 | IC50 | = | 36.0 | nM | 7.44 | Kinase Inhibition Assay: One illustrative manner in which Pim-1 kinase activity ... | - |
| Serine/threonine-protein kinase pim-1 | IC50 | = | 36.0 | nM | 7.44 | Pim-1 Kinase Inhibition Assay: One illustrative manner in which Pim-1 kinase act... | - |
Data from ChEMBL 36 via Core Engine