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Compound Detail

CHEMBL411401

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O=C1OCC2OC(=O)c3cc(O)c(O)c(O)c3-c3c(O)c(O)c(O)c4c3C(=O)OC(C2OC(=O)c2cc(O)c(O)c(O)c2-c2c1cc(O)c(O)c2O)C1OC(=O)c2c-4c(O)c(O)c(O)c2[C@@H]1c1c(O)cc(O)c2c1O[C@H](c1ccc(O)c(O)c1)[C@@H](O)C2

Basic Information

ChEMBL ID CHEMBL411401
Phase Preclinical
Structure Type MOL
InChI Key DRHVFLXLYQESEQ-JANYGAHRSA-N
3
Targets
4
Activities
2
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

1206.9
MW (Da)

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C56H38O31
MW 1206.89

Activity Summary

IC50 3 meas. best 5.16
EC50 1 meas. best 5.4

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Human immunodeficiency virus 1
CHEMBL378
EC50 5.4 5.4 4000.0 1
Protein kinase C (PKC)
CHEMBL2093867
IC50 5.16 5.16 7000.0 1
Human immunodeficiency virus 1
CHEMBL378
IC50 4.82 4.82 15000.0 1
Unchecked
CHEMBL612545
IC50 4.02 4.02 95000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1016/S0960-894X(00)80422-9 Human immunodeficiency virus 1 3
- 10.1016/S0960-894X(00)80422-9 ADMET 1
- 10.1016/S0960-894X(00)80422-9 Human immunodeficiency virus type 1 reverse transcriptase 1
- 10.1016/S0960-894X(01)81072-6 Protein kinase C (PKC) 1
- 10.1016/S0960-894X(01)81072-6 Protein kinase C, PKC; classical/novel 1
- 10.1016/S0960-894X(01)81072-6 Unchecked 1

Data from ChEMBL 36 via Core Engine