Compound Detail
CHEMBL411793
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
CC[C@@H](C)[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CCCNC(=N)N)NC(C)=O)CCCCNC(=O)CC[C@@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC1=O
Basic Information
| ChEMBL ID | CHEMBL411793 |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | RDOFKMDVEDQFIJ-WQSAXVMWSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
1699.0
MW (Da)
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 7.51
Ki 1 meas. best 7.12
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Neuropeptide Y receptor type 2 CHEMBL4018 | EC50 | 7.51 | 7.51 | 31.0 | 1 |
| Neuropeptide Y receptor type 2 CHEMBL4018 | Ki | 7.12 | 7.12 | 75.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Neuropeptide Y receptor type 2 | EC50 | = | 31.0 | nM | 7.51 | Agonist activity at human NPY2 receptor expressed in human KAN-TS cells by [35S]... | 17055726 |
| Neuropeptide Y receptor type 2 | Ki | = | 75.0 | nM | 7.12 | Displacement of human [125I]PYY from NPY2 receptor expressed in human KAN-TS cel... | 17055726 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17055726 | 10.1016/j.bmcl.2006.10.007 | Neuropeptide Y receptor type 2 | 2 |
| 17055726 | 10.1016/j.bmcl.2006.10.007 | Neuropeptide Y receptor type 1 | 1 |
| 17055726 | 10.1016/j.bmcl.2006.10.007 | Neuropeptide Y receptor type 5 | 1 |
Data from ChEMBL 36 via Core Engine