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Compound Detail

CHEMBL4126039

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O=c1oc2ccccc2c(O)c1/C=C/n1cnc2c(NCc3ccccc3)ncnc21

Basic Information

ChEMBL ID CHEMBL4126039
Phase Preclinical
Structure Type MOL
InChI Key YZTWBJFWCBHALN-ZHACJKMWSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

411.4
MW (Da)
3.88
ALogP
8
HBA
2
HBD
106.1
PSA (Ų)
0.42
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H17N5O3
MW 411.42
Aromatic Rings 5
Heavy Atoms 31
NP-Likeness -0.31

Activity Summary

IC50 1 meas. best 4.7

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Lipoxygenase
CHEMBL1641359
IC50 4.7 4.7 20000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Lipoxygenase IC50 = 20000.0 nM 4.7 Inhibition of soybean lipoxygenase 30017112

Literature References

PubMed DOI Target Context # Activities
30017112 10.1016/j.bmc.2018.05.042 Lipoxygenase 1

Data from ChEMBL 36 via Core Engine