Compound Detail
CHEMBL4128320
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL4128320 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SFMDUHOPEUGRRL-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
431.8
MW (Da)
1.98
ALogP
8
HBA
3
HBD
139.5
PSA (Ų)
0.44
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.17
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Egl nine homolog 1 CHEMBL5697 | IC50 | 7.17 | 6.22 | 67.6 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Egl nine homolog 1 | IC50 | = | 67.58 | nM | 7.17 | Inhibition of HIF-PHD2 (181 to 426 residues) (unknown origin) using FITC-HIF1-al... | 29856623 |
| Egl nine homolog 1 | IC50 | = | 5340.0 | nM | 5.27 | Inhibition of HIF-PHD2 (181 to 426 residues) (unknown origin) using HIF1-alpha (... | 29856623 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29856623 | 10.1021/acs.jmedchem.8b00549 | Egl nine homolog 1 | 5 |
Data from ChEMBL 36 via Core Engine