Compound Detail
CHEMBL414569
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)O[C@H]2[C@H](O)[C@@H](COP(=O)(O)O[C@@H]3[C@H](O)[C@@H](COP(=O)(O)O[C@@H]4[C@H](O)[C@@H](COP(=O)(O)O)O[C@H]4n4cnc5c(N)ncnc54)O[C@H]3n3cnc4c(N)ncnc43)O[C@H]2n2cnc3c(N)ncnc32)[C@@H](O)[C@H]1OP(=O)(O)O
Basic Information
| ChEMBL ID | CHEMBL414569 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ARWCLLJIZYWWEN-HCSUDTOFSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
1414.8
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 8.44
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 2-5A-dependent ribonuclease CHEMBL2687 | EC50 | 8.44 | 8.44 | 3.6 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 2-5A-dependent ribonuclease | EC50 | = | 3.6 | nM | 8.44 | Activation of mouse RNase L assessed as ability to cleave 5'-[32P]r(C11U2C7) | 16789752 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16789752 | 10.1021/jm050401v | 2-5A-dependent ribonuclease | 2 |
| 16789752 | 10.1021/jm050401v | Mus musculus | 1 |
Data from ChEMBL 36 via Core Engine