Assay Detail
Functional
CHEMBL866038
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of mouse RNase L assessed as ability to cleave 5'-[32P]r(C11U2C7)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Activation of murine RNase L by isopolar 2'-phosphonate analogues of 2',5' oligoadenylates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.61 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL427600 | — | — | 1 | 9.05 |
| CHEMBL424746 | — | — | 1 | 8.89 |
| CHEMBL414569 | — | — | 1 | 8.44 |
| CHEMBL261902 | — | — | 1 | 6.49 |
| CHEMBL434553 | — | — | 1 | 6.41 |
| CHEMBL439290 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL427600 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL424746 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL414569 | — | EC50 | = | 3.6 | nM | 8.44 |
| CHEMBL261902 | — | EC50 | = | 323.0 | nM | 6.49 |
| CHEMBL434553 | — | EC50 | = | 393.0 | nM | 6.41 |
| CHEMBL439290 | — | EC50 | = | 396.0 | nM | 6.40 |