Compound Detail
CHEMBL439290
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Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)O)[C@H](O)[C@H]1OP(=O)(O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](OP(=O)(O)OC[C@H]2O[C@@H](n3cnc4c(N)ncnc43)[C@H](OP(=O)(O)OC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)[C@H](OP(=O)(O)O)[C@@H]3O)[C@@H]2O)[C@@H]1O
Basic Information
| ChEMBL ID | CHEMBL439290 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ARWCLLJIZYWWEN-ALXODACISA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
1414.8
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 6.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 2-5A-dependent ribonuclease CHEMBL2687 | EC50 | 6.4 | 6.4 | 396.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 2-5A-dependent ribonuclease | EC50 | = | 396.0 | nM | 6.4 | Activation of mouse RNase L assessed as ability to cleave 5'-[32P]r(C11U2C7) | 16789752 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16789752 | 10.1021/jm050401v | 2-5A-dependent ribonuclease | 2 |
Data from ChEMBL 36 via Core Engine