Compound Detail
CHEMBL414819
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CSCC[C@H](NC(=O)c1cc(CC2CCCCC2)c(COc2cccnc2)cc1-c1ccccc1C)C(=O)O
Basic Information
| ChEMBL ID | CHEMBL414819 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GRKXZEYMVZRROT-PMERELPUSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
546.7
MW (Da)
6.69
ALogP
5
HBA
2
HBD
88.5
PSA (Ų)
0.26
QED
2
Ro5 Violations
12
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein farnesyltransferase CHEMBL2095178 | IC50 | 7.92 | 7.92 | 12.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein farnesyltransferase | IC50 | = | 12.0 | nM | 7.92 | In vitro inhibition of farnesyltransferase purified from bovine brain using scin... | 10479301 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10479301 | 10.1021/jm9901935 | Protein farnesyltransferase | 1 |
| 10479301 | 10.1021/jm9901935 | NIH3T3 | 1 |
Data from ChEMBL 36 via Core Engine