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Compound Detail

CHEMBL4169508

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C=C1[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H](OC(C)=O)C(C)(C)/C=C/[C@@H](C)C(=O)[C@@]2(OC(C)=O)C[C@@](C)(OC(C)=O)[C@H](OC(C)=O)[C@@H]2[C@H]1OC(C)=O

Basic Information

ChEMBL ID CHEMBL4169508
Phase Preclinical
Structure Type MOL
InChI Key CZFMBNIKGDJPJQ-QPKMLWCHSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

694.7
MW (Da)
2.65
ALogP
15
HBA
0
HBD
201.2
PSA (Ų)
0.21
QED
2
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C34H46O15
MW 694.73
Aromatic Rings 0
Heavy Atoms 49
NP-Likeness 2.27

Activity Summary

EC50 1 meas. best 4.86

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Chikungunya virus
CHEMBL4296563
EC50 4.86 4.86 13800.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Chikungunya virus EC50 = 13800.0 nM 4.86 Antiviral activity against Chikungunya virus Indian ocean strain 899 infected in... 28925702

Literature References

PubMed DOI Target Context # Activities
28925702 10.1021/acs.jnatprod.7b00113 Human immunodeficiency virus 1
28925702 10.1021/acs.jnatprod.7b00113 MT2 1
28925702 10.1021/acs.jnatprod.7b00113 Chikungunya virus 1
28925702 10.1021/acs.jnatprod.7b00113 Vero 1
28925702 10.1021/acs.jnatprod.7b00113 Unchecked 1

Data from ChEMBL 36 via Core Engine