Assay Detail
Functional
CHEMBL4133995
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Chikungunya virus Indian ocean strain 899 infected in African green monkey Vero cells assessed as reduction in virus-induced cytopathic effect by MTS assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Chikungunya virus |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Environmentally Friendly Procedure Based on Supercritical Fluid Chromatography and Tandem Mass Spectrometry Molecular Networking for the Discovery of Potent Antiviral Compounds from Euphorbia semiperfoliata.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 5.77 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279115 | PHORBOL MYRISTATE ACETATE | 2.0 | 1 | 8.54 |
| CHEMBL4170130 | — | — | 1 | 6.36 |
| CHEMBL4165007 | — | — | 1 | 6.00 |
| CHEMBL170518 | PROSTRATIN | — | 1 | 5.58 |
| CHEMBL4169508 | — | — | 1 | 4.86 |
| CHEMBL2375779 | — | — | 1 | 4.77 |
| CHEMBL4168419 | — | — | 1 | 4.29 |
| CHEMBL4174527 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279115 | PHORBOL MYRISTATE ACETATE | EC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4170130 | — | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL4165007 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL170518 | PROSTRATIN | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4169508 | — | EC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL2375779 | — | EC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL4168419 | — | EC50 | = | 51100.0 | nM | 4.29 |
| CHEMBL4174527 | — | EC50 | > | 153000.0 | nM | - |