Compound Detail
CHEMBL4169972
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Basic Information
| ChEMBL ID | CHEMBL4169972 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HZXRMIQICQMBGS-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
358.4
MW (Da)
4.61
ALogP
3
HBA
1
HBD
46.5
PSA (Ų)
0.70
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.58
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Interleukin-5 CHEMBL1163111 | IC50 | 4.58 | 4.58 | 26000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Interleukin-5 | IC50 | = | 26000.0 | nM | 4.58 | Inhibition of IL-5 in mouse Y16 cells assessed as reduction in cell proliferatio... | 29689475 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29689475 | 10.1016/j.ejmech.2018.04.030 | Interleukin-5 | 2 |
Data from ChEMBL 36 via Core Engine